If you are using spinning gear you might want to think about using a 'fused' super line, such as fireline or sufix fuse instead of a braided line. After you use braided line for a while it becomes so 'limp' that is can easily wrap around the rod tip. The fused lines aren't as limp and they don't tend to do that as often. I've used braids on my spinning stuff for a few years and I am going to be changing over to fused lines.
Using mono backing is a good way to avoid line slippage (as you and others have pointed out), using a fluorocarbon leader is a good way to reduce line visibility. I use the back to back uni knot, it's strong, not too bulky and easy to tie. If your talking about trolling applications with heavy mono you might want to look into the albright knot.
When I spool superlines I try to put the line on as tight as I can, that helps avoid the line cutting into the spool when it is under a heavy load. Usually I end up spooling it up in the house, then go outside, tie it to a post and walk out all the line, clamp down on the drag and reel it back in. I like to have it packed down on the spool nice and tight. Just be careful when doing this, you don't want a kid riding a bike clothes-lining them self on your brand new super magnum 1000000lb test (4 lbs mono dia) musky outfit!!!